9 books for « mlle b gauthier »Edit

‎Étude des chromosomes somatiques des neuf enfants mongoliens. [In: Comptes Rendus. Academies des Sciences (Paris), 1959, 248]. - [THE DISCOVERY OF TRISOMY-21 - THE CAUSE OF DOWN'S SYNDROME]‎

‎(Paris), 1959. 4to. No wrappers. Fine and clean. The paper: Pp. 1721-22. Entire issue offered pp.: (1597)-1732.‎

‎First printing of the seminal paper that first described the cause of Down's Syndrome, trisomy-21, or the presence of an extra copy of chromosome 21. ""Currently, Down syndrome (DS) is one of the most common birth defects, affecting about one in every 750 live births. John Langdon Down first described this condition in the medical literature in 1866, documenting the various symptoms associated with the syndrome but failing to determine their cause. In fact, the cause of DS remained unknown for nearly 100 years following Down's work. Then, in the 1950s [i.e. in the present paper], researchers finally determined the source of DS: the presence of an extra copy of chromosome 21, a condition often referred to as trisomy 21.Since the discovery of trisomy 21, scientists have made great strides in Down syndrome research."" (Clare O'Connor, in: Nature Education).""As previously mentioned, almost 100 years elapsed between Down's medical description of DS and the discovery of the cause of this condition. But why was this the case? It was certainly not for lack of trying. Many theories for the cause of DS were put forth in the century after Down's publication. Some physicians even made the key observation that older mothers had a higherfrequency of DS babies, and they postulated that the condition was caused by what they termed ""uterine exhaustion."" Gradually, researchers narrowed in on the real cause of DS: achromosomal abnormality. In fact, researchers now realize that older mothers have more babies with DS because the frequency of meiotic nondisjunction increases in women with age.The reason that cytologists in the early twentieth century failed to correctly diagnose DS is almost certainly due to technical limitations. Chromosome 21 is the smallest human chromosome, and procedures for examining human chromosomes were still being developed during the first part of the century. Many early cytologists had, in fact, studied chromosomes from DS patients, but none had been able to detect a supernumerary copy of chromosome 21. A breakthrough finally occurred in 1956, when Joe Hin Tjio and Albert Levan described a set of experimental conditions that allowed them to correctly identify the number of human chromosomes as 46. Within three years of the publication of this groundbreaking work, Jerome Lejeune in France and Patricia Jacobs in the United States were able to identify a supernumerary copy of chromosome 21 in karyotypes prepared from DS patients. Trisomy 21 is now accepted to be the major cause of DS, accounting for about 95% of cases."" (Clare O'Connor, in: Nature Education).Garrison & Morton: 4962.5‎

‎LECONS DE CHIMIE - BREVET SUPERIEUR ECOLES NORMALES D'INSTITUTRICES - 2EME ANNEE.‎

‎LIBRAIRIE FERNAND NATHAN. 1909. In-8. Relié. Etat d'usage, Couv. légèrement passée, Dos satisfaisant, Papier jauni. 250 pages - coiffe en pied légèrement abîmée - quelques figures en noir et blanc dans le texte.. . . . Classification Dewey : 372.8-Livre scolaire : autres matières‎

‎Préface de M.PECHARD. Classification Dewey : 372.8-Livre scolaire : autres matières‎

‎La colline enchantée, troisième livret : La famille Lapinet ( suite )‎

‎Librairie Istra 1953, fascicule de 34 pages avec des illustrations de Mme Souiller; exemplaire “ specimen “ en très bon état‎

‎Mon Foyer. Economie domestique - Enseignement ménager - Hygiène - Puériculture. Cours complémentaire. Ecoles primaires supérieures.‎

‎ 1936 P. et Strasbourg, Librairie Istra (Collection Laurent), sans date (vers 1936), in 8°, cartonnage de l'éditeur, 284 pages ; très nombreuses illustrations ; rousseurs au cartonnage. ‎

‎ ...................... Photos sur demande ..........................‎

‎MON FOYER‎

‎ISTRA. NON DATE. In-8. Broché. Bon état, Couv. convenable, Dos satisfaisant, Intérieur frais. 284 pages illustrées de schémas explicatif.. . . . Classification Dewey : 640-Economie domestique. Vie à la maison‎

‎Economie domestique, enseignement ménager, hygiène, puériculture. Cours complémentaire écoles primaires supérieurs, Ecoles normales. Collection Laurent. Classification Dewey : 640-Economie domestique. Vie à la maison‎

‎Leçons de Chimie, à l'usage des Ecoles Normales d'Institutrices. Brevet Supérieur. 2eme année : Chimie organique‎

‎NATHAN Fernand. 1908. In-12. Cartonné. Etat d'usage, Couv. défraîchie, Dos satisfaisant, Quelques rousseurs. 248 pages. Nombreuses illustrations en noir et blanc, dans le texte. Quelques pages détachées. Tampon sur la page de titre.. . . . Classification Dewey : 540-Chimie et sciences connexes‎

‎Préface de M. Péchard. Classification Dewey : 540-Chimie et sciences connexes‎

‎MON FOYER. ENSEIGNEMENT MENAGER, ECONOMIE DOMESTIQUE, HYGIENE, PUERICULTURE. COURS COMPLEMENTAIRE, COLLEGES. PROGRAMME DU 2e CYCLE.‎

‎LIBRAIRIE ISTRA. 1947. In-8. Cartonné. Bon état, Couv. convenable, Dos satisfaisant, Intérieur frais. 284 pages. Dos de toile bleue.. . . . Classification Dewey : 372.8-Livre scolaire : autres matières‎

‎ Classification Dewey : 372.8-Livre scolaire : autres matières‎

‎La Colline Enchantée. 2ème livret : La Famille Lapinet (Suite).‎

‎LIBRAIRIE ISTRA. 1962. In-8. Broché. Très bon état, Couv. fraîche, Dos satisfaisant, Intérieur frais. Livret de 35 pages. Nombreux dessins en couleurs, dans le texte, par Mme SOUILLER. . . A l'italienne. Classification Dewey : 370-Education‎

‎ Classification Dewey : 370-Education‎

‎LECONS DE PHYSIQUE, A L'USAGE DES ECOLES NORMALES D'INSTITUTRICES ET DES ECOLES PRIMAIRES SUPERIEURES DE JEUNES FILLES, PREPARATION DU BREVET SUPERIEUR‎

‎Nathan. Non daté. In-12. Relié. Etat d'usage, Tâchée, Dos abîmé, Intérieur acceptable. 383 + 396 pages. Illustré de nombreuses gravures en noir et blanc dans le texte. Couverture détachée. 1re page de garde abîmée et tachée.. . . . Classification Dewey : 530-Physique‎

‎Optique. Magnétisme. Electricité... Classification Dewey : 530-Physique‎